He was one of the first to use the drug in the UK, as Chief Investigator for a scientific study. He has continued to use the surgical drug in routine clinical practice, having performed over 360 injections by October 2015. He has also performed over 1000 operations for Dupuytren’s. Professor Warwick has led the training for use of this drug in the whole of Europe, as Chairman of the Xiapex Advisory Board. He is the lead author on several peer reviewed publications and book chapters. He is Editor in chief of the comprehensive European book on Dupuytren’s Disease. His own results have been presented at national and international meetings.

Downloads :

Download the PDF Download the information sheet (Oct 2015) on collagenase here.

Download the PDF Download the Xiapex Consent Form here.

Download the PDF Collagenase Clostridium histolyticum: emerging practice patterns and treatment advances.

In 2010 it was given approval by the FDA (Federal Drugs Administration ) in the USA; in 2011 it was given approval by the European Medicines Agency and then by the UK.

The evidence which led to the approval by the FDA and European Medicines Agency can be seen below:


Links (open in new window)

The surgical drug is be available at David Warwick’s Hand Clinic at the Nuffield Wessex to insured patients (subject to confirmation from their insurance carrier) and to self-funding patients. NHS treatment is not presently available but is being sought.

Contact The Hand Clinic

For more information please contact me direcly or via my PA Rachel:

0345 4505 007
Professor David Warwick
Rachel Hecks (PA)

The Hand Clinic
Nuffield Hospital
Winchester Road
Chandlers Ford
SO53 2DW


Follow on Twitter